对乙酰氨基酚(APAP)过量是药物性肝损伤(DILI)的主要原因。但是目前肠道微生物群和相关代谢物对APAP和肝功能的影响仍不清楚。最近,南方医科大学团队在期刊《Cell Host & Microbe》(IF=31.316)上发表题为“Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.”的文章,该篇研究发现APAP紊乱与独特的肠道微生物群落有关,即阴道乳酸杆菌明显减少。由于细菌β-半乳糖苷酶从饮食中释放异黄酮大豆苷元,接受阴道毛滴虫的小鼠显示出对APAP肝毒性的抗性。用β-半乳糖苷酶抑制剂消除了阴道毛滴虫对APAP暴露的无菌小鼠的肝保护作用。类似地,β-半乳糖苷酶缺陷型阴道毛滴虫在APAP处理的小鼠中比野生型小鼠产生更差的结果,但是这些差异通过大豆苷元给药得以克服。大豆黄酮阻止了铁死亡,这与法尼二磷酸合酶(Fdps)表达下降有关,该合酶激活了涉及AKT-GSK3β-Nrf2的关键铁死亡途径。该研究证明了阴道乳酸杆菌β-半乳糖苷酶释放大豆苷元抑制了Fdps介导的肝细胞铁死亡,为药物性肝损伤提供了新的治疗方法。
本文中使用了欣博盛Mouse TNF-α, MCP-1 和IL-6 ELISA kits检测了血浆中这些细胞因子的含量。
1.文章题目:Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
期 刊:Cell Host & Microbe(影响因子:31.316)
发表时间:25 April 2023
作 者:Zeng Y, Wu R, Wang F, et al.
作者单位:南方医科大学
使用产品:Mouse TNF-α, IL-6, and MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37100057/
2.文章题目:Enhanced Proliferation of Visualizable Mesenchymal Stem Cell–Platelet Hybrid Cell for Versatile Intracerebral Hemorrhage Treatment.
期 刊:ACS nano(影响因子:18.027)
发表时间:10 April 2023
作 者:Wu G, Liu Z, Mu C, et al.
作者单位:北京理工大学
使用产品:Mouse IL-6, IL-1βand TNF-α ELISA kits
样本类型:脑组织
https://pubmed.ncbi.nlm.nih.gov/37037487/
3.文章题目:AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling.
期 刊:Nature Communications(影响因子:17.694)
发表时间:20 April 2023
作 者:Da X, Li Z, Huang X, et al.
作者单位:华中科技大学
使用产品:Human TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37081014/
4.文章题目:Neutrophil-inspired photothermo-responsive drug delivery system for targeted treatment of bacterial infection and endotoxins neutralization.
期 刊:Biomaterials Research(影响因子:15.863)
发表时间:15 April 2023
作 者:Li C, Gan Y, Li Z, et al.
作者单位:中山大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37061741/
5.文章题目:Reversible adhesives with controlled wrinkling patterns for programmable integration and discharging.
期 刊:Science Advances(影响因子:14.957)
发表时间:12 April 2023
作 者:Zhou Y, Yang L, Liu Z, et al.
作者单位:南方医科大学
使用产品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37043582/
6.文章题目:Increased reactive oxygen species lead to overactivation of platelets in essential thrombocythemia.
期 刊:Thrombosis Research(影响因子:10.407)
发表时间:10 April 2023
作 者:Dong H, Li H, Fang L, et al.
作者单位:中国医学科学院血液病研究所
使用产品:Human PF4 ELISA kit;Mouse PF4 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37087805/
7.文章题目:CXC Chemokine Receptor Type 4 Antagonistic Gold Nanorods Induce Specific Immune Responses and Long-Term Immune Memory to Combat Triple-Negative Breast Cancer.
期 刊:ACS Applied Materials & Interfaces(影响因子:10.383)
发表时间:5 April 2023
作 者:Meng Y, Zhou J, Liu X, et al.
作者单位:中国医学科学院基础医学研究所
使用产品:Mouse TNF-α and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37017641/
8.文章题目:Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m6A-dependent manner.
期 刊:Clinical Immunology(影响因子:10.19)
发表时间:6 April 2023
作 者:Xiang S, Wang Y, Lei D, et al.
作者单位:重庆医科大学
使用产品:TMB底物
https://pubmed.ncbi.nlm.nih.gov/37030526/
9.文章题目:Cascade amplification of tumor chemodynamic therapy and starvation with re-educated TAMs via Fe-MOF based functional nanosystem.
期 刊:Journal of Nanobiotechnology(影响因子:9.429)
发表时间:11 April 2023
作 者:Zheng X, Li X, Meng S, et al.
作者单位:西北工业大学
使用产品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/37041537/
10.文章题目:Allergenicity reduction of cow milk treated by alkaline protease combined with Lactobacillus Plantarum and Lactobacillus helveticus based on epitopes.
期 刊:Food Chemistry(影响因子:9.231)
发表时间:15 April 2023
作 者:Ye M, Xu Z, Tan H, et al.
作者单位:南昌大学
使用产品:TMB底物
https://pubmed.ncbi.nlm.nih.gov/37105121/
11.文章题目:Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy.
期 刊:Journal of Medicinal Chemistry(影响因子:8.039)
发表时间:20 April 2023
作 者:Zhu Y, Zhou M, Cheng X, et al.
作者单位:苏州大学
使用产品:Mouse TNF-α and IL-1β ELISA kits
样本类型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/37078976/
12.文章题目:Structural characterization and immunomodulatory activity of a polysaccharide from finger citron extracted by continuous phase-transition extraction.
期 刊:International Journal of Biological Macromolecules(影响因子:8.025)
发表时间:17 April 2023
作 者:Wang S, Yang Y, Wang Q, et al.
作者单位:华南农业大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37076066/
13.文章题目:Theasinensin A attenuated diabetic development by restoring glucose homeostasis, improving hepatic steatosis and modulating gut microbiota in high-fat-diet/streptozotocin-induced diabetic mice.
期 刊:Food Science and Human Wellness (影响因子:8.022)
发表时间:4 April 2023
作 者:Xu W, Huang Y, Zhou W, et al.
作者单位:南京农业大学
使用产品:Mouse TNF-α, IL-1β, IL-6 and IL-10 ELISA kits
https://www.sciencedirect.com/science/article/pii/S2213453023000782
14.文章题目:Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice.
期 刊:Food Science and Human Wellness(影响因子:8.022)
发表时间:4 April 2023
作 者:Li J, Guo Y, Ma L, et al.
作者单位:集美大学
使用产品:Mouse IFN-γ, IL-4, IL-10 and IL-22 ELISA kits
样本类型:小肠组织
https://www.sciencedirect.com/science/article/pii/S221345302300099X
15.文章题目:Milk fat globule membrane supplementation protects against β-lactoglobulin-induced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier in a microbiota-derived short-chain fatty acids manner.
期 刊:Food Science and Human Wellness(影响因子:8.022)
发表时间:14 April 2023
作 者:Gong H, Li T, Liang D, et al.
作者单位:中国农业大学
使用产品:Mouse IFN-γ and IL-4 ELISA kits
https://www.sciopen.com/article/10.26599/FSHW.2022.9250010
16.文章题目:A manganese-phenolic network platform amplifying STING activation to potentiate MRI guided cancer chemo-/chemodynamic/immune therapy.
期 刊:Biomaterials Science(影响因子:7.59)
发表时间:19 April 2023
作 者:Pang X, Fu C, Chen J, et al.
作者单位:华南理工大学
使用产品:Mouse IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37074080/
17.文章题目:Sirt4 deficiency promotes the development of atherosclerosis by activating the NF-κB/IκB/CXCL2/3 pathway.
期 刊:Atherosclerosis(影响因子:6.847)
发表时间:21 April 2023
作 者:Chang S, Zhang G, Li L, et al.
作者单位:滨州医学院
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0021915023001764
18.文章题目:Construction of sandwich ELISA method for quantitative detection of α-lactalbumin in hypoallergenic formula based on a novel monoclonal antibody prepared by the recombinant protein.
期 刊:Food Control(影响因子:6.652)
发表时间:17 April 2023
作 者:Tan H, Chen S, Qiu Y, et al.
作者单位:南昌大学
使用产品:TMB底物
https://www.sciencedirect.com/science/article/abs/pii/S0956713523002001
19.文章题目:MiR-126-Loaded Immunoliposomes against Vascular Endothelial Inflammation In Vitro and Vivo Evaluation.
期 刊:Pharmaceutics(影响因子:6.525)
发表时间:30 April 2023
作 者:Tang Y, Chen Y, Guo Q, et al.
作者单位:贵州医科大学
使用产品:Mouse IL-1β and IL-6 ELISA kits
https://www.mdpi.com/1999-4923/15/5/1379
20.文章题目:A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet induced mice.
期 刊:Food & Function(影响因子:6.317)
发表时间:10 April 2023
作 者:Zhou W, Liu P, Xu W, et al.
作者单位:南京农业大学
使用产品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubs.rsc.org/en/content/articlelanding/2023/fo/d3fo00262d/unauth
21.文章题目:Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.
期 刊:Food & Function(影响因子:6.317)
发表时间:17 April 2023
作 者:Chen F, Chu C, Wang X, et al.
作者单位:东南大学
使用产品:Mouse MCP-1 ELISA kit
样本类型:肠道组织
https://pubmed.ncbi.nlm.nih.gov/37067254/
22.文章题目:ABCG2 plays a central role in the dysregulation of 25-hydrovitamin D in Crohn's disease.
期 刊:The Journal of Nutritional Biochemistry(影响因子:6.117)
发表时间:21 April 2023
作 者:Peng J, Song X, Zhu F, et al.
作者单位:重庆理工大学
使用产品:Human CRP, TNF-α, IL-6 and IL-8 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37087072/
文章题目:Development of a new cellular immunological detection method for tuberculosis based on HupB protein induced IL-6 release test.
期 刊:Frontiers in Microbiology(影响因子:6.064)
发表时间:3 April 2023
作 者:Yu X, Jiang S, Li Y, et al.
作者单位:武汉工业大学
使用产品:Human IL-6 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37077246/
24.文章题目:Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation.
期 刊:Frontiers in Endocrinology(影响因子:6.055)
发表时间:1 April 2023
作 者:Du T, Xiang L, Zhang J, et al.
作者单位:西南医科大学
使用产品:Rat TNF-α, IL-6 and MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37033263/
25.文章题目:Sirtuin 1 activator alleviated lethal inflammatory injury via promotion of autophagic degradation of pyruvate kinase M2.
期 刊:Frontiers in Pharmacology(影响因子:5.988)
发表时间:10 April 2023
作 者:Zhao S, Sun Y, Wu X, et al.
作者单位:重庆医科大学
使用产品:Mouse TNF-α, IL-6, and MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37101542/
26.文章题目:Epitope Mapping of Lysozyme Using the Chinese Egg-Allergic Sera at Both Pooled and Individual Levels.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:13 April 2023
作 者:Wang Q, Ju D, Gao J, et al.
作者单位:南昌大学
使用产品:TMB底物
https://pubmed.ncbi.nlm.nih.gov/37053565/
27.文章题目:Dextran-Sulfate-Sodium-Induced Colitis-Ameliorating Effect of Aqueous Phyllanthus emblica L. Extract through Regulating Colonic Cell Gene Expression and Gut Microbiomes.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:27 April 2023
作 者:Li X, Ouyang W, Jiang Y, et al.
作者单位:华南理工大学
使用产品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37102314/
28.文章题目:Construction of an Antithrombotic and Anti‐Inflammatory Polyethersulfone Membrane.
期 刊:Macromolecular Bioscience(影响因子:5.859)
发表时间:14 April 2023
作 者:Fu X, Lei T, Tang C, et al.
作者单位:中南大学
使用产品:Human CRP, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37057668/
29.文章题目:Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated Ca2+ Entry Pathway.
期 刊:Allergy, Asthma & Immunology Research(影响因子:5.096)
发表时间:1 April 2023
作 者:Huang J H, Gao H W, Gao D D, et al.
作者单位:澳门科技大学
使用产品:Mouse IL-4 ELISA kit
样本类型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/37075798/
30.文章题目:Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice.
期 刊: Toxins(影响因子:5.075)
发表时间:1 April 2023
作 者:Yang Y, Zheng S, Chu H, et al.
作者单位:中南大学
使用产品:Mouse IL-1β, IL-6, TNF-α, and IL-10 ELISA kits
https://www.mdpi.com/2072-6651/15/4/262
31.文章题目:Naproxen-Derived New Compound Inhibits the NF-κB, MAPK and PI3K/Akt Signaling Pathways Synergistically with Resveratrol in RAW264. 7 Cells.
期 刊:Molecules(影响因子:4.927)
发表时间:12 April 2023
作 者:Ou Y, You Z, Yao M, et al.
作者单位:五邑大学
使用产品:Mouse IL-6 ELISA kit
https://www.mdpi.com/1420-3049/28/8/3395
32.文章题目:CD40LG and GZMB were correlated with adipose tissue macrophage infiltration and involved in obstructive sleep apnea related metabolic dysregulation: Evidence from bioinformatics analysis.
期 刊:Frontiers in Genetics(影响因子:4.772)
发表时间:1 April 2023
作 者:Ming X, Cai W, Li Z, et al.
作者单位:武汉大学
使用产品:Human CRP, sCD40L and Granzyme B ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36923793/
33.文章题目:Electroacupuncture Pretreatment at Zusanli (ST36) Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice by Reducing Oxidative Stress via Activating Vagus Nerve-Dependent Nrf2 Pathway.
期 刊:Journal of Inflammation Research(影响因子:4.631)
发表时间:17 April 2023
作 者:Jiang H, Shang Z, You L, et al.
作者单位:上海中医药大学附属曙光医院
使用产品:Mouse IL-6, TNF-α, and IL-1β ELISA kits
https://www.tandfonline.com/doi/full/10.2147/JIR.S404087
34.文章题目:Herbal Medicine Dihydroartemisinin Inhibits Colorectal Cancer by Regulafing PI3K/AKT Signal-ing Pathway.
期 刊:Journal of Oncology(影响因子:4.501)
发表时间:1 April 2023
作 者:Xu J R, Jia F J, Yao G T, et al.
作者单位:香港浸会大学
使用产品:Rat TNF-α ELISA kit
http://journalononcology.org/pdf/1080.pdf
35.文章题目:Pax6-induced proliferation and differentiation of bone marrow mesenchymal stem cells into limbal epithelial stem cells.
期 刊:Stem Cells and Development(影响因子:4.39)
发表时间:25 April 2023
作 者:Gao J, Ding L, Xin Y, et al.
作者单位:贵州医科大学
使用产品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37097204/
36.文章题目:Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway.
期 刊:Immunology Letters(影响因子:4.23)
发表时间:29 April 2023
作 者:Liu Y, Yuan Y, Zhou Z, et al.
作者单位:电子科技大学
使用产品:Mouse IL-17A, IL-6, IFN-γ IL-1β and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37121553/
37.文章题目:Energy intake restriction significantly improves POCD after internal fixation of tibial fractures in mice.
期 刊:American Journal of Translational Research(影响因子:3.94)
发表时间:1 April 2023
作 者:Xie W, Sun J, Zheng J, et al.
作者单位:福建医科大学
使用产品:Mouse IL-1β, IL-6, IL-8 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37056861/
38.文章题目:Enhanced anti-rheumatoid arthritis activity of total alkaloids from Picrasma quassioides in collagen-induced arthritis rats by a targeted drug delivery system.
期 刊:Journal of Pharmaceutical Sciences(影响因子:3.784)
发表时间:5 April 2023
作 者:Yuan H, Liu B, Liu F, et al.
作者单位:中国药科大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37023852/
39.文章题目:DDB1 regulates the activation-induced apoptosis of T cells via downregulating the expression of histone methyltransferase SETD7.
期 刊:Medical Oncology(影响因子:3.738)
发表时间:12 April 2023
作 者:Wu R, Wu X, Zou L, et al.
作者单位:江南大学
使用产品:Mouse TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37043057/
40.文章题目:Betaine regulates adipogenic and osteogenic differentiation of hAD-MSCs.
期 刊:Molecular Biology Reports(影响因子:2.742)
发表时间:26 April 2023
作 者:Jing Y, Zhou J, Guo F, et al.
作者单位:沈阳化工大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37101008/
41.文章题目:Different effects of a perioperative single dose of dexamethasone on wound healing in mice with or without sepsis.
期 刊:Frontiers in Surgery(影响因子:2.568)
发表时间:11 April 2023
作 者:Chen Y, Chen X, Zhou Q.
作者单位:上海交通大学附属医院
使用产品:Mouse IL-6, TNF-α, and IL-10 ELISA kits
样本类型:皮肤组织
https://pubmed.ncbi.nlm.nih.gov/37114154/
42.文章题目:Effects of irradiation with different fractionations on radioresistant esophageal cancer cells and lung tissues.
期 刊:Journal of Radiation Research and Applied Sciences(影响因子:1.773)
发表时间:18 April 2023
作 者:Wang L, Xu S, Yang B, et al.
作者单位:重庆大学
使用产品:Mouse TGF-β1 ELISA kit
https://www.sciencedirect.com/science/article/pii/S1687850723000523
43.文章题目:Porcine Deltacoronavirus-like Particles Produced by a Single Recombinant Baculovirus Elicit Virus-Specific Immune Responses in Mice.
期 刊:Viruses(影响因子:1.723)
发表时间:29 April 2023
作 者:Liu Y, Han X, Qiao Y, et al.
作者单位:南阳师范学院
使用产品:Mouse IFN-γ and IL-4 ELISA kits
https://www.mdpi.com/1999-4915/15/5/1095
44.文章题目:Role of activating the nuclear factor kappa B signaling pathway in the development of septic cardiomyopathy in rats with sepsis.
期 刊:Technology and Health Care(影响因子:1.205)
发表时间:21 April 2023
作 者:Xing X R, Luo L P, Li Y L, et al.
作者单位:江苏科技大学
使用产品:Rat TNF-α, IL-1βand IL-6 ELISA kits