乳酸(LA)的过量产生可能发生在运动期间或者许多疾病中,例如癌症中。个人伴有高乳酸血症的患者常表现为贫血、血清铁减少以及一种铁代谢关键调控因子—铁调素(hepcidin)升高。然而,目前尚不清楚乳酸是否以及如何调节铁调素的表达。最近,中国科学院生态环境科学研究中心在期刊《Cell Metabolism》(IF=29)上发表题为“Lactate modulates iron metabolism by binding soluble adenylyl cyclase.”的文章,展示乳酸与正常肝细胞中的可溶性腺苷酸环化酶(sAC)结合,并影响正常肝细胞中的全身铁稳态 上调小鼠铁调素的表达。全面的体外、体内和计算机实验表明 LA-sAC相互作用提高了环磷酸腺苷(cAMP)水平,从而激活PKA-Smad1/5/8信号通路,增加铁调素转录。同时在野生型小鼠和铁稳态紊乱的小鼠中验证了这一调节轴。LA也调节人体静息状态下和经受大量运动条件下的铁调素。该研究将高乳酸血症与缺铁联系起来,为运动员和乳酸酸中毒患者的贫血提供了一个全新的机制的阐述。
本文中使用了欣博盛Human IL-6(快速检测) and CRP ELISA kit and Mouse IL-6 ELISA kit(快速检测)检测了血清样本中目标蛋白的含量。
1.文章题目:Lactate modulates iron metabolism by binding soluble adenylyl cyclase.
期 刊:Cell Metabolism(影响因子:29)
发表时间:21 July 2023
作 者:Liu W, Zhang S, Li Q, et al.
作者单位:中国科学院生态环境科学研究中心
使用产品:Human IL-6(Quick Test) and CRP ELISA kit and Mouse IL-6 ELISA kit(Quick Test)
https://pubmed.ncbi.nlm.nih.gov/37480842/
2.文章题目:Precisely Amplifying Intracellular Oxidative Storm by Metal–Organic Coordination Polymers to Augment Anticancer Immunity.
期 刊:ACS nano(影响因子:17.1)
发表时间:25 July 2023
作 者:Li S, Chen X, Guan S, et al.
作者单位:中国药科大学
使用产品:Mouse IL-6, IFN-γ, TNF-α and IL-12p70 ELISA kits
https://pubs.acs.org/doi/abs/10.1021/acsnano.3c04785
3.文章题目:Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1.
期 刊:Nature Communications(影响因子:16.6)
发表时间:20 July 2023
作 者:Gao Y, Chi Y, Chen Y, et al.
作者单位:中国医学科学院&北京协和医科大学
使用产品:Human TNF-α and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37474525/
4.文章题目:A PDA‐Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy.
期 刊:Advanced Science(影响因子:15.1)
发表时间:9 July 2023
作 者:Zhang W, Chen Y, Li M, et al.
作者单位:河南科技大学第一附属医院
使用产品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/37424037/
5.文章题目:Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils.
期 刊:Acta Pharmaceutica Sinica B(影响因子:14.5)
发表时间:24 July 2023
作 者:Hua P, Liang R, Tu Y, et al.
作者单位:澳门大学
使用产品:Rat TNF-α, IL-6 and IL-1β ELISA kits
https://www.sciencedirect.com/science/article/pii/S2211383523002836
6.文章题目:Acetylation at the O-6 position of t-Glc improved immunoactivity of α-1, 6-glucan from longan by additionally activating Dectin-1 and CD14 receptors.
期 刊:Carbohydrate Polymers(影响因子:11.2)
发表时间:13 July 2023
作 者:Liu L, Lan H, Wang Y, et al.
作者单位:华南农业大学
使用产品:Mouse IL-6, TNF-α and IL-10 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0144861723006641
7.文章题目:Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter.
期 刊:Environmental Health Perspectives(影响因子:10.4)
发表时间:17 July 2023
作 者:Zhang R, Chen S, Wang Z, et al.
作者单位:中山大学
使用产品:Mouse IL-17A, IL-1βand TGF-β ELISA kits
样本类型:肺组织
https://pubmed.ncbi.nlm.nih.gov/37458712/
8.文章题目:Platelet-derived exosomes hybrid liposomes facilitate uninterrupted singlet oxygen generation to enhance breast cancer immunotherapy.
期 刊:Cell Reports Physical Science(影响因子:8.9)
发表时间:19 July 2023
作 者:Ning S, Zhang X, Suo M, et al.
作者单位:广西医科大学
使用产品:Mouse IFN-γ and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S2666386423002898.
9.文章题目:T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity.
期 刊:Cell Reports(影响因子:8.8)
发表时间:15 July 2023
作 者:Cui Y, Yuan T, Wang Y, et al.
作者单位:中国科学院广州生物医药与健康研究院
使用产品:Human IgG(Total) ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37436890/
10.文章题目:Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
期 刊:Journal of Pharmaceutical Analysis(影响因子:8.8)
发表时间:17 July 2023
作 者:Linghu K G, Zhang T, Zhang G T, et al.
作者单位:澳门大学
使用产品:Mouse IL-6, IL-8, MCP-1, and IFN-γ ELISA kits
https://www.sciencedirect.com/science/article/pii/S209517792300148X
11.文章题目:A frog peptide provides new strategies for the intervention against skin wound healing.
期 刊:Cellular & Molecular Biology Letters(影响因子:8.3)
发表时间:28 July 2023
作 者:Li C, Fu Z, Jin T, et al.
作者单位:昆明医科大学
使用产品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37501100/
12.文章题目:The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism.
期 刊:International Journal of Biological Macromolecules(影响因子:8.2)
发表时间:1 July 2023
作 者:Shu Y, Huang Y, Dong W, et al.
作者单位:南京农业大学
使用产品:Mouse TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37399869/
13.文章题目:Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia.
期 刊:Journal of Translational Medicine(影响因子:7.4)
发表时间:28 July 2023
作 者:Zhou J, Zhao Y, An P, et al.
作者单位:复旦大学
使用产品:Mouse TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37507742/
14.文章题目:20 (S)‐Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis.
期 刊:Phytotherapy Research(影响因子:7.2)
发表时间:9 July 2023
作 者:Chen J, Lu P, Liu J, et al.
作者单位:澳门大学
使用产品:Mouse/Human TNF-α, IL-1β, IL-18 and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37424151/
15.文章题目:Cryptotanshinone alleviates radiation‐induced lung fibrosis via modulation of gut microbiota and bile acid metabolism.
期 刊:Phytotherapy Research(影响因子:7.2)
发表时间:10 July 2023
作 者:Li Z, Shen Y, Xin J, et al.
作者单位:广东药科大学
使用产品:Mouse IL-6, IL-1β and TNF-α ELISA kits
样本样本:肺组织
https://pubmed.ncbi.nlm.nih.gov/37427974/
16.文章题目:Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation.
期 刊:European Journal of Medicinal Chemistry(影响因子:6.7)
发表时间:18 July 2023
作 者:Huang J, Ma Z, Yang Z, et al.
作者单位:南方医科大学药学院
使用产品:Mouse IL-1β and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37487306/
17.文章题目:Therapeutic effects against high-grade glioblastoma mediated by engineered induced neural stem cells combined with GD2-specific CAR-NK.
期 刊:Cellular Oncology(影响因子:6.6)
发表时间:7 July 2023
作 者:Liu W, Zhao Y, Liu Z, et al.
作者单位:首都医科大学
使用产品:Human IFN-γ and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37420122/
18.文章题目:Drug-Embedded Nanovesicles Assembled from Peptide-Decorated Hyaluronic Acid for Rheumatoid Arthritis Synergistic Therapy.
期 刊:Biomacromolecules(影响因子:6.2)
发表时间:7 July 2023
作 者:Hu Q, Zhang F, Wei Y, et al.
作者单位:四川大学华西医院
使用产品:Mouse TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37417966/
19.文章题目:A biodegradable hollow nanoagent enables a boosted chemodynamic therapy by simultaneous autophagy inhibition and macrophage reeducation.
期 刊:International Journal of Pharmaceutics(影响因子:5.8)
发表时间:17 July 2023
作 者:Zhu H, Gao X, Wang B, et al.
作者单位:河北大学
使用产品:Mouse TNF-α, IL-10, and IL-12p40 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37467817/
20.文章题目:Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages.
期 刊:Molecular Medicine(影响因子:5.7)
发表时间:24 July 2023
作 者:Wang Y, Wan R, Hu C.
作者单位:中南大学湘雅医院
使用产品:Human Leptin ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37488474/
21.文章题目:Suppression of TLR4 prevents diabetic bone loss by regulating FTO-mediated m6A modification.
期 刊:International Immunopharmacology(影响因子:5.6)
发表时间:4 July 2023
作 者:Shen X, Lan C, Lin Y, et al.
作者单位:福建医科大学
使用产品:Rat insulin ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37413932/
22.文章题目:The ratio of total IgE level at week 16 to baseline significantly correlated with the clinical response to omalizumab in moderate to severe allergic rhinitis patients.
期 刊:International Immunopharmacology(影响因子:5.6)
发表时间:11 July 2023
作 者:Zhao Z, Deng Y, Xiang L, et al.
作者单位:武汉大学人民医院
使用产品:Anti mouse IgG-HRP
https://pubmed.ncbi.nlm.nih.gov/37441810/
23.文章题目:Hypoxic postconditioning drives protective microglial responses and ameliorates white matter injury after ischemic stroke.
期 刊:CNS Neuroscience & Therapeutics(影响因子:5.5)
发表时间:12 July 2023
作 者:Zhang W, Li S, Yun H J, et al.
作者单位:首都医科大学
使用产品:Mouse IL-1β, IL-10 and TGF-β1 ELISA kits
样本类型:脑组织
https://pubmed.ncbi.nlm.nih.gov/37435771/
24.文章题目: Garcimultiflins A–C, unusual polycyclic polyprenylated acylphloroglucinols from the pericarps of Garcinia multiflora as interleukin-1β and pyroptosis inhibitors.
期 刊:Organic Chemistry Frontiers(影响因子:5.4)
发表时间:17 July 2023
作 者:Cao J, Chen J, Du R, et al.
作者单位:澳门大学
使用产品:Mouse IL-1β and TNF-α ELISA kits
https://pubs.rsc.org/en/content/articlelanding/2023/qo/d3qo00752a/unauth
25.文章题目:Pyroptosis by NLRP3/caspase‐1/gasdermin‐D pathway in synovial tissues of rheumatoid arthritis patients.
期 刊:Journal of Cellular and Molecular Medicine(影响因子:5.3)
发表时间:1 July 2023
作 者:Zhang X, Wang Q, Cao G, et al.
作者单位:洛阳骨科医院
使用产品:Human IL-1β and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37386795/
26.文章题目:MALAT1/miR‐185‐5p mediated high glucose‐induced oxidative stress, mitochondrial injury and cardiomyocyte apoptosis via the RhoA/ROCK pathway.
期 刊:Journal of Cellular and Molecular Medicine(影响因子:5.3)
发表时间:3 July 2023
作 者:Wang T, Li N, Yuan L, et al.
作者单位:河北医科大学
使用产品:Annexin V-FITC/PI detection Kit
https://pubmed.ncbi.nlm.nih.gov/37395157/
27.文章题目:Treponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and NF-κB signalling pathways.
期 刊:Biochimica et Biophysica Acta (BBA)-Molecular Cell Research(影响因子:5.1)
发表时间:17 July 2023
作 者:Zheng X Q, Kong X Q, He Y, et al.
作者单位:厦门大学医学院
使用产品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37468070/
28.文章题目:Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression.
期 刊:Arthritis Research & Therapy(影响因子:4.9)
发表时间:19 July 2023
作 者:Lv L, Jiang H, Song D, et al.
作者单位:川北医学院
使用产品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37468929/
29.文章题目:Semen Ziziphus jujube Saponins Protects HaCaT Cells against UV Damage and Alleviates the Aging of Caenorhabditis elegans.
期 刊:ACS Omega(影响因子:4.1)
发表时间:25 July 2023
作 者:Hao K X, Xie H, Jiang J G, et al.
作者单位:华南理工大学
使用产品:Human MMP-1 ELISA kit
https://pubs.acs.org/doi/full/10.1021/acsomega.3c00433
30.文章题目:Jing-Fang powder ethyl acetate extracts attenuate atopic dermatitis by modulating T-cell activity.
期 刊:Molecular Immunology(影响因子:3.6)
发表时间:8 July 2023
作 者:Zhao G, Tong Y, Xu J, et al.
作者单位:成都中医药大学
使用产品:Human IL-2 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37429064/
31.文章题目:Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3× Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway.
期 刊:Journal of Dairy Science(影响因子:3.5)
发表时间:4 July 2023
作 者:Li Y, Zhang Z H, Huang S L, et al.
作者单位:深圳大学
使用产品:Mouse IFN-γ, IL-1β, IL-6, TNF-α, IL-4 and IL-10 ELISA kits
样本类型:大脑皮层匀浆
https://pubmed.ncbi.nlm.nih.gov/37414601/
32.文章题目:Improvement of hemodynamics in mesenteric microcirculationin septic shock rats by anisodamine and anisodine.
期 刊:Mechanobiology in Medicine(影响因子:3.5)
发表时间:5 July 2023
作 者:Zhong J, Ouyang Z, Shen J, et al.
作者单位:四川大学
使用产品:Rat IL-6 and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S2949907023000062
33.文章题目:Hepatoprotective effect of total flavonoids from Carthamus tinctorius L. leaves against carbon tetrachloride-induced chronic liver injury in mice.
期 刊:Fitoterapia(影响因子:3.4)
发表时间:10 July 2023
作 者:Ma M, Chen L, Tang Z, et al.
作者单位:陕西中医药大学
使用产品:Mouse IL-1β and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37437698/
34.文章题目:PDGF-BB/PDGFRβ induces tumour angiogenesis via enhancing PKM2 mediated by the PI3K/AKT pathway in Wilms’ tumour.
期 刊:Medical Oncology(影响因子:3.4)
发表时间:14 July 2023
作 者:Sang B, Wang C, Liu X, et al.
作者单位:重庆医科大学
使用产品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37442847/
35.文章题目:Influences of lysine‐specific demethylase 1 inhibitors on NO synthase–Kruppel‐like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) larvae in vivo.
期 刊:Journal of Applied Toxicology(影响因子:3.3)
发表时间:5 July 2023
作 者:Yuan J, Que R, Zhao W, et al.
作者单位:南华大学
使用产品:Human IL-8 and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37408164/
36.文章题目:Pro-angiogenic activity of salvianolate and its potential therapeutic effect against acute cerebral ischemia.
期 刊:Experimental and Therapeutic Medicine(影响因子:2.7)
发表时间:10 July 2023
作 者:Xu J, Shen Y, Luan P, et al.
作者单位:青岛大学
使用产品:Mouse VEGF ELISA kits
https://www.spandidos-publications.com/10.3892/etm.2023.12108
37.文章题目:Exercise Plus Acupuncture on Consensus Acupoints Versus Acupoints Selected by the Theory of Equal Impact on Tendons, Bones, and Muscles for Knee Osteoarthritis.
期 刊:Alternative Therapies in Health and Medicine(影响因子:1.5)
发表时间:29 July 2023
作 者:Wang Y.
作者单位:河北中医药大学
使用产品:Human IL-1β and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37052974/