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Research Article

Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles

    Yingying Xu

    Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry & Molecular Engineering, Peking University, Beijing, China

    Authors contributed equally

    Search for more papers by this author

    ,
    Huan Tang

    Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry & Molecular Engineering, Peking University, Beijing, China

    Authors contributed equally

    Search for more papers by this author

    ,
    Haifang Wang

    *Author for correspondence:

    E-mail Address: yliu@pku.edu.cn

    ;

    E-mail Address: hwang@shu.edu.cn

    Institute of Nanochemistry & Nanobiology, Shanghai University, Shanghai, China

    &
    Yuanfang Liu

    *Author for correspondence:

    E-mail Address: yliu@pku.edu.cn

    ;

    E-mail Address: hwang@shu.edu.cn

    Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry & Molecular Engineering, Peking University, Beijing, China

    Institute of Nanochemistry & Nanobiology, Shanghai University, Shanghai, China

    Published Online:https://doi.org/10.2217/nnm.14.111

    Aim: The authors investigated the effect of silver nanoparticles (Ag NPs) on oral tolerance to dietary antigen ovalbumin (OVA) in mice. Materials & methods: Ag NPs were orally administered for 7 days before feeding of OVA and the immunological responses were assayed. Results: Polyvinyl pyrrolidone-coated Ag NPs (Ag NPs-PVP) were found to block the induction of oral tolerance to OVA. The physicochemical properties of the three kinds of Ag NPs were assessed and silver ions were found to inhibit the induction of oral tolerance, which might be the dominating factor in the blockade of oral tolerance by Ag NPs-PVP. Conclusion: Ag NPs with certain physicochemical properties can block oral tolerance to dietary antigen that may induce food allergy in humans.

    Papers of special note have been highlighted as: • of interest

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