Abstract
Aim: The authors investigated the effect of silver nanoparticles (Ag NPs) on oral tolerance to dietary antigen ovalbumin (OVA) in mice. Materials & methods: Ag NPs were orally administered for 7 days before feeding of OVA and the immunological responses were assayed. Results: Polyvinyl pyrrolidone-coated Ag NPs (Ag NPs-PVP) were found to block the induction of oral tolerance to OVA. The physicochemical properties of the three kinds of Ag NPs were assessed and silver ions were found to inhibit the induction of oral tolerance, which might be the dominating factor in the blockade of oral tolerance by Ag NPs-PVP. Conclusion: Ag NPs with certain physicochemical properties can block oral tolerance to dietary antigen that may induce food allergy in humans.
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